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Rapid and Precise Engineering of the Caenorhabditis elegans Genome with Lethal Mutation Co-Conversion and Inactivation of NHEJ Repair
As in other organisms, CRISPR/Cas9 methods provide a powerful approach for genome editing in the nematode Caenorhabditis elegans. Oligonucleotides are excellent repair templates for introducing substitutions and short insertions, as they are cost effective, require no cloning, and appear in other or...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Genetics Society of America
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317648/ https://www.ncbi.nlm.nih.gov/pubmed/25491644 http://dx.doi.org/10.1534/genetics.114.172361 |