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Methylation-induced downregulation of TFPI-2 causes TMPRSS4 overexpression and contributes to oncogenesis in a subset of non-small-cell lung carcinoma

We identified transmembrane protease, serine 4 (TMPRSS4) as a putative, druggable target by screening surgically resected samples from 90 Japanese non-small-cell lung cancer (NSCLC) patients using cDNA microarray. TMPRSS4 has two druggable domains and was upregulated in 94.5% of the lung cancer spec...

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Detalles Bibliográficos
Autores principales:	Hamamoto, Junko, Soejima, Kenzo, Naoki, Katsuhiko, Yasuda, Hiroyuki, Hayashi, Yuichiro, Yoda, Satoshi, Nakayama, Sohei, Satomi, Ryosuke, Terai, Hideki, Ikemura, Shinnosuke, Sato, Takashi, Arai, Daisuke, Ishioka, Kota, Ohgino, Keiko, Betsuyaku, Tomoko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317784/ https://www.ncbi.nlm.nih.gov/pubmed/25414083 http://dx.doi.org/10.1111/cas.12569

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