2-Methoxystypandrone inhibits signal transducer and activator of transcription 3 and nuclear factor-κB signaling by inhibiting Janus kinase 2 and IκB kinase

Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) or the nuclear factor-κB (NF-κB) pathway occurs frequently in cancer cells and contributes to oncogenesis. The activation of Janus kinase 2 (JAK2) and IκB kinase (IKK) are key events in STAT3 and NF-κB signalin...

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Detalles Bibliográficos
Autores principales: Kuang, Shan, Qi, Chunting, Liu, Jiawei, Sun, Xiaoxiao, Zhang, Qing, Sima, Zhenhua, Liu, Jingli, Li, Wuguo, Yu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317813/
https://www.ncbi.nlm.nih.gov/pubmed/24450414
http://dx.doi.org/10.1111/cas.12359

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