N1-guanyl-1,7-diaminoheptane sensitizes bladder cancer cells to doxorubicin by preventing epithelial–mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2 activation

Drug resistance greatly reduces the efficacy of doxorubicin-based chemotherapy in bladder cancer treatment; however, the underlying mechanisms are poorly understood. We aimed to investigate whether N1-guanyl-1,7-diaminoheptane (GC7), which inhibits eukaryotic translation initiation factor 5A2 (eIF5A...

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Detalles Bibliográficos
Autores principales: Yang, Jinsong, Yu, Haogang, Shen, Mo, Wei, Wei, Xia, Lihong, Zhao, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317814/
https://www.ncbi.nlm.nih.gov/pubmed/24262005
http://dx.doi.org/10.1111/cas.12328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317814/
https://www.ncbi.nlm.nih.gov/pubmed/24262005
http://dx.doi.org/10.1111/cas.12328

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