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Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer

Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) play important roles in the immune escape of cancer. In this study, we investigated pDCs and pDC-induced inducible costimulator (ICOS)(+) Treg populations in peripheral blood from gastric cancer (GC) patients and healthy donors by fl...

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Autores principales: Huang, Xiao-Mei, Liu, Xiao-Sun, Lin, Xian-Ke, Yu, Hang, Sun, Jian-Yi, Liu, Xiao-Kun, Chen, Chao, Jin, Hai-Long, Zhang, Ge-Er, Shi, Xiao-Xiao, Zhang, Qing, Yu, Ji-Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317822/
https://www.ncbi.nlm.nih.gov/pubmed/24261990
http://dx.doi.org/10.1111/cas.12327
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author Huang, Xiao-Mei
Liu, Xiao-Sun
Lin, Xian-Ke
Yu, Hang
Sun, Jian-Yi
Liu, Xiao-Kun
Chen, Chao
Jin, Hai-Long
Zhang, Ge-Er
Shi, Xiao-Xiao
Zhang, Qing
Yu, Ji-Ren
author_facet Huang, Xiao-Mei
Liu, Xiao-Sun
Lin, Xian-Ke
Yu, Hang
Sun, Jian-Yi
Liu, Xiao-Kun
Chen, Chao
Jin, Hai-Long
Zhang, Ge-Er
Shi, Xiao-Xiao
Zhang, Qing
Yu, Ji-Ren
author_sort Huang, Xiao-Mei
collection PubMed
description Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) play important roles in the immune escape of cancer. In this study, we investigated pDCs and pDC-induced inducible costimulator (ICOS)(+) Treg populations in peripheral blood from gastric cancer (GC) patients and healthy donors by flow cytometry. The distribution of these cells in carcinoma tissue, peritumor tissue, and normal gastric mucosa was detected by immunohistochemistry. Plasma and tissue concentration of the cytokines such as interleukin-10 and transforming growth factor-β1 were also measured. We found that the numbers of pDCs, Tregs, and ICOS(+) Tregs in peripheral blood were increased in GC patients compared with healthy donors. In tissue, Tregs and ICOS(+) Tregs were found distributing mainly in carcinoma tissue, whereas pDCs were mainly found in peritumor tissue. Moreover, the Foxp3(+)ICOS(+)/Foxp3(+) cell ratio in carcinoma and peritumor tissue were higher than that in normal tissue. There were more ICOS(+) Tregs in tumor and peritumor tissue of late-stage GC patients. There was a positive correlation between pDCs and ICOS(+) Tregs in peripheral blood and peritumor tissue from GC patients. In conclusion, pDCs may play a potential role in recruiting ICOS(+) Tregs, and both participate in the immunosuppression microenvironment of GC.
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spelling pubmed-43178222015-10-05 Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer Huang, Xiao-Mei Liu, Xiao-Sun Lin, Xian-Ke Yu, Hang Sun, Jian-Yi Liu, Xiao-Kun Chen, Chao Jin, Hai-Long Zhang, Ge-Er Shi, Xiao-Xiao Zhang, Qing Yu, Ji-Ren Cancer Sci Original Articles Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) play important roles in the immune escape of cancer. In this study, we investigated pDCs and pDC-induced inducible costimulator (ICOS)(+) Treg populations in peripheral blood from gastric cancer (GC) patients and healthy donors by flow cytometry. The distribution of these cells in carcinoma tissue, peritumor tissue, and normal gastric mucosa was detected by immunohistochemistry. Plasma and tissue concentration of the cytokines such as interleukin-10 and transforming growth factor-β1 were also measured. We found that the numbers of pDCs, Tregs, and ICOS(+) Tregs in peripheral blood were increased in GC patients compared with healthy donors. In tissue, Tregs and ICOS(+) Tregs were found distributing mainly in carcinoma tissue, whereas pDCs were mainly found in peritumor tissue. Moreover, the Foxp3(+)ICOS(+)/Foxp3(+) cell ratio in carcinoma and peritumor tissue were higher than that in normal tissue. There were more ICOS(+) Tregs in tumor and peritumor tissue of late-stage GC patients. There was a positive correlation between pDCs and ICOS(+) Tregs in peripheral blood and peritumor tissue from GC patients. In conclusion, pDCs may play a potential role in recruiting ICOS(+) Tregs, and both participate in the immunosuppression microenvironment of GC. Blackwell Publishing Ltd 2014-02 2014-01-04 /pmc/articles/PMC4317822/ /pubmed/24261990 http://dx.doi.org/10.1111/cas.12327 Text en © 2013 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Huang, Xiao-Mei
Liu, Xiao-Sun
Lin, Xian-Ke
Yu, Hang
Sun, Jian-Yi
Liu, Xiao-Kun
Chen, Chao
Jin, Hai-Long
Zhang, Ge-Er
Shi, Xiao-Xiao
Zhang, Qing
Yu, Ji-Ren
Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer
title Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer
title_full Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer
title_fullStr Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer
title_full_unstemmed Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer
title_short Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer
title_sort role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory t cells in the immunosuppression microenvironment of gastric cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317822/
https://www.ncbi.nlm.nih.gov/pubmed/24261990
http://dx.doi.org/10.1111/cas.12327
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