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Not just gRASping at flaws: Finding vulnerabilities to develop novel therapies for treating KRAS mutant cancers
Mutations in Kirsten rat-sarcoma (KRAS) are well appreciated to be major drivers of human cancers through dysregulation of multiple growth and survival pathways. Similar to many other non-kinase oncogenes and tumor suppressors, efforts to directly target KRAS pharmaceutically have not yet materializ...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BlackWell Publishing Ltd
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317830/ https://www.ncbi.nlm.nih.gov/pubmed/24612015 http://dx.doi.org/10.1111/cas.12383 |