Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein of rapamycin pathway in multiple myeloma cells

In multiple myeloma (MM), the hypoxic environment is an important factor causing tumor angiogenesis, which is strongly correlated to disease progression and unfavorable outcome by activating the key transcription factor, hypoxia-inducible factor-1α (HIF-1α). Gambogic acid (GA) is the major active in...

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Detalles Bibliográficos
Autores principales: Wang, Fei, Zhang, Wei, Guo, Liting, Bao, Wen, Jin, Nan, Liu, Ran, Liu, Ping, Wang, Yonghui, Guo, Qinglong, Chen, Baoan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317858/
https://www.ncbi.nlm.nih.gov/pubmed/24890366
http://dx.doi.org/10.1111/cas.12458

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