Cargando…

Lenvatinib in combination with golvatinib overcomes hepatocyte growth factor pathway-induced resistance to vascular endothelial growth factor receptor inhibitor

Vascular endothelial growth factor receptor (VEGFR) inhibitors are approved for the treatment of several tumor types; however, some tumors show intrinsic resistance to VEGFR inhibitors, and some patients develop acquired resistance to these inhibitors. Therefore, a strategy to overcome VEGFR inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakagawa, Takayuki, Matsushima, Tomohiro, Kawano, Satoshi, Nakazawa, Youya, Kato, Yu, Adachi, Yusuke, Abe, Takanori, Semba, Taro, Yokoi, Akira, Matsui, Junji, Tsuruoka, Akihiko, Funahashi, Yasuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317894/ https://www.ncbi.nlm.nih.gov/pubmed/24689876 http://dx.doi.org/10.1111/cas.12409

Ejemplares similares

Multitargeting strategy using lenvatinib and golvatinib: Maximizing anti-angiogenesis activity in a preclinical cancer model
por: Nakazawa, Youya, et al.
Publicado: (2015)

Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models
por: Matsuki, Masahiro, et al.
Publicado: (2018)

Targeting of tumor growth and angiogenesis underlies the enhanced antitumor activity of lenvatinib in combination with everolimus
por: Matsuki, Masahiro, et al.
Publicado: (2017)

Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage
por: Yamamoto, Yuji, et al.
Publicado: (2014)

Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor–tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models
por: Ito, Ken, et al.
Publicado: (2014)

Hepatocyte growth factor and the hepatocyte growth factor receptor signalling complex as targets in cancer therapies
por: Jiang, W.G.
Publicado: (2007)

Hepatocyte growth factor, hepatocyte growth factor activator and arginine in a rat fulminant colitis model
por: Zwintscher, Nathan P., et al.
Publicado: (2016)

Hepatocyte Growth Factor and Cardiac Amyloidosis
por: Ruberg, Frederick L., et al.
Publicado: (2020)

Bronchioalveolar morphogenesis of human bronchial epithelial cells depending upon hepatocyte growth factor
por: Kato, Takashi, et al.
Publicado: (2015)

Epidermal growth factor receptor activation confers resistance to lenvatinib in thyroid cancer cells
por: Ohno, Koichi, et al.
Publicado: (2022)

Hepatocyte Growth Factor: A Microenvironmental Resource for Leukemic Cell Growth
por: Giannoni, Paolo, et al.
Publicado: (2019)

Effects of hepatocyte growth factor on porcine mammary cell growth and senescence
por: Huang, Chi-Ping, et al.
Publicado: (2023)

Periostin blockade overcomes chemoresistance via restricting the expansion of mesenchymal tumor subpopulations in breast cancer
por: Nakazawa, Youya, et al.
Publicado: (2018)

Hepatocyte growth factor is crucial for development of the carapace in turtles
por: Kawashima-Ohya, Yoshie, et al.
Publicado: (2011)

Hepatocyte Growth Factor and Clinical Diabetes in Postmenopausal Women
por: Rajpathak, Swapnil N., et al.
Publicado: (2010)

Mechanisms of Hepatocyte Growth Factor Activation in Cancer Tissues
por: Kawaguchi, Makiko, et al.
Publicado: (2014)

Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease
por: Sharma, Shiv K.
Publicado: (2010)

Hepatocyte growth factor predicts failure of Fontan circulation
por: Kojima, Takuro, et al.
Publicado: (2020)

Immunomodulatory activity of lenvatinib contributes to antitumor activity in the Hepa1‐6 hepatocellular carcinoma model
por: Kimura, Takayuki, et al.
Publicado: (2018)

Ferroptosis is induced by lenvatinib through fibroblast growth factor receptor‐4 inhibition in hepatocellular carcinoma
por: Iseda, Norifumi, et al.
Publicado: (2022)

Antitumor Activity of Lenvatinib (E7080): An Angiogenesis Inhibitor That Targets Multiple Receptor Tyrosine Kinases in Preclinical Human Thyroid Cancer Models
por: Tohyama, Osamu, et al.
Publicado: (2014)

Function of hepatocyte spheroids in bioactive microcapsules is enhanced by endogenous and exogenous hepatocyte growth factor
por: Gwon, Kihak, et al.
Publicado: (2023)

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
Publicado: (1992)

Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6
por: Volz, Yvonne, et al.
Publicado: (2015)

Efficacy of lenvatinib combined with sequential transarterial chemoembolization for primary hepatocellular carcinoma and the effects on serum basic fibroblast growth factor and vascular endothelial growth factor
por: Xie, Qing-Yun, et al.
Publicado: (2022)

Serum APOA4 Pharmacodynamically Represents Administered Recombinant Human Hepatocyte Growth Factor (E3112)
por: Motoi, Sotaro, et al.
Publicado: (2021)

Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time
por: Motoi, Sotaro, et al.
Publicado: (2019)

Hepatocyte growth factor stimulates neutrophil degranulation but not respiratory burst
por: Kowanko, I. C., et al.
Publicado: (1993)

Hepatocyte and keratinocyte growth factors and their receptors in human lung emphysema
por: Bonay, Marcel, et al.
Publicado: (2005)

The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis
Publicado: (1995)

Association of the Hepatocyte Growth Factor Gene with Keratoconus in an Australian Population
por: Sahebjada, Srujana, et al.
Publicado: (2014)

The Role of Hepatocyte Growth Factor (HGF) in Insulin Resistance and Diabetes
por: Oliveira, Alexandre G., et al.
Publicado: (2018)

Modulation of Motility and Proliferation of Glioma Cells by Hepatocyte Growth Factor
por: Yamamoto, Shinji, et al.
Publicado: (1997)

Hepatocyte growth factor/MET in cancer progression and biomarker discovery
por: Matsumoto, Kunio, et al.
Publicado: (2017)

Function of hepatocyte growth factor in gastric cancer proliferation and invasion
por: Koh, Sung Ae, et al.
Publicado: (2020)

Suppression of lipopolysaccharide-induced corneal opacity by hepatocyte growth factor
por: Elbasiony, Elsayed, et al.
Publicado: (2022)

Rilotumumab Resistance Acquired by Intracrine Hepatocyte Growth Factor Signaling
por: Cecchi, Fabiola, et al.
Publicado: (2023)

Ezetimibe ameliorates atherogenic lipids profiles, insulin resistance and hepatocyte growth factor in obese patients with hypercholesterolemia
por: Adachi, Hisashi, et al.
Publicado: (2015)

Hepatocyte Growth Factor, a Key Tumor-Promoting Factor in the Tumor Microenvironment
por: Owusu, Benjamin Yaw, et al.
Publicado: (2017)

Fibrosis growth factor 23 is a promoting factor for cardiac fibrosis in the presence of transforming growth factor-β1
por: Kuga, Kazuhiro, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pe4237botolhjlbcm67tti6nvo