Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma

Cholangiocarcinoma is an aggressive malignant tumor originating from intrahepatic or extrahepatic bile ducts. Its malignant phenotypes may be assumed by cancer stem cells (CSC). Here, we demonstrate that CD274 (PD-L1), known as an immunomodulatory ligand, has suppressive effects on CSC-related pheno...

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Detalles Bibliográficos
Autores principales: Tamai, Keiichi, Nakamura, Mao, Mizuma, Masamichi, Mochizuki, Mai, Yokoyama, Misa, Endo, Hiroyuki, Yamaguchi, Kazunori, Nakagawa, Takayuki, Shiina, Masaaki, Unno, Michiaki, Muramoto, Koji, Sato, Ikuro, Satoh, Kennichi, Sugamura, Kazuo, Tanaka, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317902/
https://www.ncbi.nlm.nih.gov/pubmed/24673799
http://dx.doi.org/10.1111/cas.12406

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