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RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer

Although epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (EGFR-TKI), including gefitinib, provide a significant clinical benefit in non-small-cell lung cancer (NSCLC) patients, the acquisition of drug resistance has been known to limit the efficacy of EGFR-TKI therapy. In this stu...

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Detalles Bibliográficos
Autores principales:	Kaneto, Naoki, Yokoyama, Satoru, Hayakawa, Yoshihiro, Kato, Shinichiro, Sakurai, Hiroaki, Saiki, Ikuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317907/ https://www.ncbi.nlm.nih.gov/pubmed/24750242 http://dx.doi.org/10.1111/cas.12425

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