Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma

The newly synthesized naftopidil analogue HUHS1015 reduced cell viability in malignant pleural mesothelioma cell lines MSTO-211H, NCI-H28, NCI-H2052, and NCI-H2452, with the potential greater than that for the anticancer drugs paclitaxel or cisplatin at concentrations higher than 30 μM. HUHS1015 ind...

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Autores principales: Kaku, Yoshiko, Nagaya, Hisao, Tsuchiya, Ayako, Kanno, Takeshi, Gotoh, Akinobu, Tanaka, Akito, Shimizu, Tadashi, Nakao, Syuhei, Tabata, Chiharu, Nakano, Takashi, Nishizaki, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317914/
https://www.ncbi.nlm.nih.gov/pubmed/24754309
http://dx.doi.org/10.1111/cas.12429
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author Kaku, Yoshiko
Nagaya, Hisao
Tsuchiya, Ayako
Kanno, Takeshi
Gotoh, Akinobu
Tanaka, Akito
Shimizu, Tadashi
Nakao, Syuhei
Tabata, Chiharu
Nakano, Takashi
Nishizaki, Tomoyuki
author_facet Kaku, Yoshiko
Nagaya, Hisao
Tsuchiya, Ayako
Kanno, Takeshi
Gotoh, Akinobu
Tanaka, Akito
Shimizu, Tadashi
Nakao, Syuhei
Tabata, Chiharu
Nakano, Takashi
Nishizaki, Tomoyuki
author_sort Kaku, Yoshiko
collection PubMed
description The newly synthesized naftopidil analogue HUHS1015 reduced cell viability in malignant pleural mesothelioma cell lines MSTO-211H, NCI-H28, NCI-H2052, and NCI-H2452, with the potential greater than that for the anticancer drugs paclitaxel or cisplatin at concentrations higher than 30 μM. HUHS1015 induced both necrosis and apoptosis of MSTO-211H and NCI-H2052 cells. HUHS1015 upregulated expression of mRNAs for Puma, Hrk, and Noxa in MSTO-211H and NCI-H2052 cells, suggesting HUHS1015-induced mitochondrial apoptosis. HUHS1015 clearly suppressed tumor growth in mice inoculated with NCI-H2052 cells. Taken together, the results of the present study indicate that HUHS1015 could be developed as an effective anticancer drug for treatment of malignant pleural mesothelioma.
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spelling pubmed-43179142015-10-05 Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma Kaku, Yoshiko Nagaya, Hisao Tsuchiya, Ayako Kanno, Takeshi Gotoh, Akinobu Tanaka, Akito Shimizu, Tadashi Nakao, Syuhei Tabata, Chiharu Nakano, Takashi Nishizaki, Tomoyuki Cancer Sci Original Articles The newly synthesized naftopidil analogue HUHS1015 reduced cell viability in malignant pleural mesothelioma cell lines MSTO-211H, NCI-H28, NCI-H2052, and NCI-H2452, with the potential greater than that for the anticancer drugs paclitaxel or cisplatin at concentrations higher than 30 μM. HUHS1015 induced both necrosis and apoptosis of MSTO-211H and NCI-H2052 cells. HUHS1015 upregulated expression of mRNAs for Puma, Hrk, and Noxa in MSTO-211H and NCI-H2052 cells, suggesting HUHS1015-induced mitochondrial apoptosis. HUHS1015 clearly suppressed tumor growth in mice inoculated with NCI-H2052 cells. Taken together, the results of the present study indicate that HUHS1015 could be developed as an effective anticancer drug for treatment of malignant pleural mesothelioma. Blackwell Publishing Ltd 2014-07 2014-05-21 /pmc/articles/PMC4317914/ /pubmed/24754309 http://dx.doi.org/10.1111/cas.12429 Text en © 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Kaku, Yoshiko
Nagaya, Hisao
Tsuchiya, Ayako
Kanno, Takeshi
Gotoh, Akinobu
Tanaka, Akito
Shimizu, Tadashi
Nakao, Syuhei
Tabata, Chiharu
Nakano, Takashi
Nishizaki, Tomoyuki
Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma
title Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma
title_full Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma
title_fullStr Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma
title_full_unstemmed Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma
title_short Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma
title_sort newly synthesized anticancer drug huhs1015 is effective on malignant pleural mesothelioma
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317914/
https://www.ncbi.nlm.nih.gov/pubmed/24754309
http://dx.doi.org/10.1111/cas.12429
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