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Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in Wistar albino rats
CONTEXT: Gastric ulcer is one of the most prevalent gastrointestinal disorders. A number of studies have been carried out to determine the efficacy of herbal medicines in the treatment of gastric ulcer. OBJECTIVES: The present study was undertaken to evaluate the anti-ulcerogenic activity of methano...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318100/ https://www.ncbi.nlm.nih.gov/pubmed/25664267 http://dx.doi.org/10.4103/2229-516X.149238 |
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author | Oluwabunmi, Ige Janet Abiola, Tijani |
author_facet | Oluwabunmi, Ige Janet Abiola, Tijani |
author_sort | Oluwabunmi, Ige Janet |
collection | PubMed |
description | CONTEXT: Gastric ulcer is one of the most prevalent gastrointestinal disorders. A number of studies have been carried out to determine the efficacy of herbal medicines in the treatment of gastric ulcer. OBJECTIVES: The present study was undertaken to evaluate the anti-ulcerogenic activity of methanol extract of Gomphrena celosioides (GC) in male Wistar rats. MATERIALS AND METHODS: The rats were divided into eight groups, methanol extract of GC was administered orally, for seven consecutive to five groups. On the 7(th) day, indomethacin was administered to induce gastric ulceration. Gastric secretions were collected and analyzed. RESULTS: Animals pretreated with GC extract showed a significant reduction in ulcer score, ulcer index, gastric volume, and gastric total acidity in indomethacin-induced ulcer models in a dose dependent manner when compared to the ulcerated control group. CONCLUSION: The study revealed gastroprotective activity of the extract in dose-dependent manner. Methanol extract of the leaves of GC was significantly effective in protecting the gastric mucosa against indomethacin-induced ulcers at all the dose level studied. |
format | Online Article Text |
id | pubmed-4318100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43181002015-02-06 Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in Wistar albino rats Oluwabunmi, Ige Janet Abiola, Tijani Int J Appl Basic Med Res Original Article CONTEXT: Gastric ulcer is one of the most prevalent gastrointestinal disorders. A number of studies have been carried out to determine the efficacy of herbal medicines in the treatment of gastric ulcer. OBJECTIVES: The present study was undertaken to evaluate the anti-ulcerogenic activity of methanol extract of Gomphrena celosioides (GC) in male Wistar rats. MATERIALS AND METHODS: The rats were divided into eight groups, methanol extract of GC was administered orally, for seven consecutive to five groups. On the 7(th) day, indomethacin was administered to induce gastric ulceration. Gastric secretions were collected and analyzed. RESULTS: Animals pretreated with GC extract showed a significant reduction in ulcer score, ulcer index, gastric volume, and gastric total acidity in indomethacin-induced ulcer models in a dose dependent manner when compared to the ulcerated control group. CONCLUSION: The study revealed gastroprotective activity of the extract in dose-dependent manner. Methanol extract of the leaves of GC was significantly effective in protecting the gastric mucosa against indomethacin-induced ulcers at all the dose level studied. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4318100/ /pubmed/25664267 http://dx.doi.org/10.4103/2229-516X.149238 Text en Copyright: © International Journal of Applied and Basic Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Oluwabunmi, Ige Janet Abiola, Tijani Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in Wistar albino rats |
title | Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in Wistar albino rats |
title_full | Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in Wistar albino rats |
title_fullStr | Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in Wistar albino rats |
title_full_unstemmed | Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in Wistar albino rats |
title_short | Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in Wistar albino rats |
title_sort | gastroprotective effect of methanolic extract of gomphrena celosioides on indomethacin induced gastric ulcer in wistar albino rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318100/ https://www.ncbi.nlm.nih.gov/pubmed/25664267 http://dx.doi.org/10.4103/2229-516X.149238 |
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