TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis

The mechanisms by which TGF-β promotes lung adenocarcinoma (ADC) metastasis are largely unknown. Here, we report that in lung ADC cells, TGF-β potently induces expression of DOCK4, but not other DOCK family members, via the Smad pathway and that DOCK4 induction mediates TGF-β’s prometastatic effects...

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Detalles Bibliográficos
Autores principales: Yu, Jia-Ray, Tai, Yilin, Jin, Ying, Hammell, Molly C., Wilkinson, J. Erby, Roe, Jae-Seok, Vakoc, Christopher R., Van Aelst, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318142/
https://www.ncbi.nlm.nih.gov/pubmed/25644601
http://dx.doi.org/10.1101/gad.248963.114

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