PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1

PR domain-containing 16 (PRDM16) induces expression of brown fat-specific genes in brown and beige adipocytes, although the underlying transcription-related mechanisms remain largely unknown. Here, in vitro studies show that PRDM16, through its zinc finger domains, directly interacts with the MED1 s...

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Detalles Bibliográficos
Autores principales: Iida, Satoshi, Chen, Wei, Nakadai, Tomoyoshi, Ohkuma, Yoshiaki, Roeder, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318147/
https://www.ncbi.nlm.nih.gov/pubmed/25644605
http://dx.doi.org/10.1101/gad.252809.114

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