Decreased expression of cell proliferation-related genes in clonally derived skin fibroblasts from children with Silver-Russell syndrome is independent of the degree of 11p15 ICR1 hypomethylation

BACKGROUND: The in vitro analysis of the hypomethylation of imprinting control region 1 (ICR1) within the IGF2/H19 locus is challenged by the mosaic distribution of the epimutation in tissues from children with Silver-Russell syndrome (SRS). To exclude mosaicism, clonal cultures of skin fibroblasts...

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Detalles Bibliográficos
Autores principales: Heckmann, Doreen, Urban, Christina, Weber, Karin, Kannenberg, Kai, Binder, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318184/
https://www.ncbi.nlm.nih.gov/pubmed/25657826
http://dx.doi.org/10.1186/s13148-014-0038-0

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