Increased sample volume and use of quantitative reverse-transcription PCR can improve prediction of liver-to-blood inoculum size in controlled human malaria infection studies

BACKGROUND: Controlled human malaria infection (CHMI) studies increasingly rely on nucleic acid test (NAT) methods to detect and quantify parasites in the blood of infected participants. The lower limits of detection and quantification vary amongst the assays used throughout the world, which may aff...

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Detalles Bibliográficos
Autores principales: Hodgson, Susanne H, Douglas, Alexander D, Edwards, Nick J, Kimani, Domtila, Elias, Sean C, Chang, Ming, Daza, Glenda, Seilie, Annette M, Magiri, Charles, Muia, Alfred, Juma, Elizabeth A, Cole, Andrew O, Rampling, Thomas W, Anagnostou, Nicholas A, Gilbert, Sarah C, Hoffman, Stephen L, Draper, Simon J, Bejon, Philip, Ogutu, Bernhards, Marsh, Kevin, Hill, Adrian VS, Murphy, Sean C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318195/
https://www.ncbi.nlm.nih.gov/pubmed/25627033
http://dx.doi.org/10.1186/s12936-015-0541-6

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