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The Multifaceted Role of the Vasculature in Endochondral Fracture Repair
Fracture healing is critically dependent upon an adequate vascular supply. The normal rate for fracture delayed or non-union is estimated to be between 10 and 15%, and annual fracture numbers are approximately 15 million cases per year. However, when there is decreased vascular perfusion to the frac...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318416/ https://www.ncbi.nlm.nih.gov/pubmed/25699016 http://dx.doi.org/10.3389/fendo.2015.00004 |
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author | Bahney, Chelsea S. Hu, Diane P. Miclau, Theodore Marcucio, Ralph S. |
author_facet | Bahney, Chelsea S. Hu, Diane P. Miclau, Theodore Marcucio, Ralph S. |
author_sort | Bahney, Chelsea S. |
collection | PubMed |
description | Fracture healing is critically dependent upon an adequate vascular supply. The normal rate for fracture delayed or non-union is estimated to be between 10 and 15%, and annual fracture numbers are approximately 15 million cases per year. However, when there is decreased vascular perfusion to the fracture, incidence of impaired healing rises dramatically to 46%. Reduction in the blood supply to the fracture can be the result of traumatic injuries that physically disrupt the vasculature and damage supportive soft tissue, the result of anatomical location (i.e., distal tibia), or attributed to physiological conditions such as age, diabetes, or smoking. The role of the vasculature during repair is multifaceted and changes during the course of healing. In this article, we review recent insights into the role of the vasculature during fracture repair. Taken together these data highlight the need for an updated model for endochondral repair to facilitate improved therapeutic approaches to promote bone healing. |
format | Online Article Text |
id | pubmed-4318416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43184162015-02-19 The Multifaceted Role of the Vasculature in Endochondral Fracture Repair Bahney, Chelsea S. Hu, Diane P. Miclau, Theodore Marcucio, Ralph S. Front Endocrinol (Lausanne) Endocrinology Fracture healing is critically dependent upon an adequate vascular supply. The normal rate for fracture delayed or non-union is estimated to be between 10 and 15%, and annual fracture numbers are approximately 15 million cases per year. However, when there is decreased vascular perfusion to the fracture, incidence of impaired healing rises dramatically to 46%. Reduction in the blood supply to the fracture can be the result of traumatic injuries that physically disrupt the vasculature and damage supportive soft tissue, the result of anatomical location (i.e., distal tibia), or attributed to physiological conditions such as age, diabetes, or smoking. The role of the vasculature during repair is multifaceted and changes during the course of healing. In this article, we review recent insights into the role of the vasculature during fracture repair. Taken together these data highlight the need for an updated model for endochondral repair to facilitate improved therapeutic approaches to promote bone healing. Frontiers Media S.A. 2015-02-05 /pmc/articles/PMC4318416/ /pubmed/25699016 http://dx.doi.org/10.3389/fendo.2015.00004 Text en Copyright © 2015 Bahney, Hu, Miclau and Marcucio. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Bahney, Chelsea S. Hu, Diane P. Miclau, Theodore Marcucio, Ralph S. The Multifaceted Role of the Vasculature in Endochondral Fracture Repair |
title | The Multifaceted Role of the Vasculature in Endochondral Fracture Repair |
title_full | The Multifaceted Role of the Vasculature in Endochondral Fracture Repair |
title_fullStr | The Multifaceted Role of the Vasculature in Endochondral Fracture Repair |
title_full_unstemmed | The Multifaceted Role of the Vasculature in Endochondral Fracture Repair |
title_short | The Multifaceted Role of the Vasculature in Endochondral Fracture Repair |
title_sort | multifaceted role of the vasculature in endochondral fracture repair |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318416/ https://www.ncbi.nlm.nih.gov/pubmed/25699016 http://dx.doi.org/10.3389/fendo.2015.00004 |
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