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Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study
OBJECTIVE: This study aimed to describe and compare the nutritional status of adult patients submitted to allogeneic hematopoietic stem cell transplantation at two different time points (admission and discharge). METHODS: A retrospective, descriptive and quantitative study was performed based on cli...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Hematologia e Hemoterapia
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318470/ https://www.ncbi.nlm.nih.gov/pubmed/25453651 http://dx.doi.org/10.1016/j.bjhh.2014.07.014 |
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author | Ferreira, Érika Elias Guerra, Daiane Cristina Baluz, Kátia de Resende Furtado, Wander da Silva Bouzas, Luis Fernando |
author_facet | Ferreira, Érika Elias Guerra, Daiane Cristina Baluz, Kátia de Resende Furtado, Wander da Silva Bouzas, Luis Fernando |
author_sort | Ferreira, Érika Elias |
collection | PubMed |
description | OBJECTIVE: This study aimed to describe and compare the nutritional status of adult patients submitted to allogeneic hematopoietic stem cell transplantation at two different time points (admission and discharge). METHODS: A retrospective, descriptive and quantitative study was performed based on clinical, laboratory and nutritional data obtained from medical records of adult patients of both genders submitted to allogeneic hematopoietic stem cell transplantation in a bone marrow transplantation reference center in Rio de Janeiro in the period from 2010 to 2013. Statistical analysis was performed using the SPSS software (version 22.0). RESULTS: Sixty-four patients were evaluated. The mean age was 42.1 ± 3.2 years and the most prevalent disease was acute myeloid leukemia (39%). There was a high prevalence of gastrointestinal symptoms including nausea (100%), vomiting (97%) and mucositis (93%). Between admission and discharge there was a significant decrease in the median weight (−2.5 kg; 71.5 vs. 68.75 kg; p-value < 0.001), body mass index (−0.9 kg/m(2); 24.8 vs. 24.4 kg/m(2); p-value < 0.001), and serum albumin levels (−0.2 g/dL; 3.7 vs. 3.6 g/dL; p-value = 0.024). The survival time after hematopoietic stem cell transplantation correlated negatively with C-reactive protein at discharge (CC = −0.72; p-value < 0.001) and positively with serum albumin levels (CC = 0.56; p-value = 0.004) and with high total protein level at discharge (CC = 0.53; p-value = 0.006). CONCLUSION: Our results suggest that patients submitted to allogeneic hematopoietic stem cell transplantation have compromised nutritional status during the hospital stay for transplantation. |
format | Online Article Text |
id | pubmed-4318470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Sociedade Brasileira de Hematologia e Hemoterapia |
record_format | MEDLINE/PubMed |
spelling | pubmed-43184702015-02-19 Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study Ferreira, Érika Elias Guerra, Daiane Cristina Baluz, Kátia de Resende Furtado, Wander da Silva Bouzas, Luis Fernando Rev Bras Hematol Hemoter Original Article OBJECTIVE: This study aimed to describe and compare the nutritional status of adult patients submitted to allogeneic hematopoietic stem cell transplantation at two different time points (admission and discharge). METHODS: A retrospective, descriptive and quantitative study was performed based on clinical, laboratory and nutritional data obtained from medical records of adult patients of both genders submitted to allogeneic hematopoietic stem cell transplantation in a bone marrow transplantation reference center in Rio de Janeiro in the period from 2010 to 2013. Statistical analysis was performed using the SPSS software (version 22.0). RESULTS: Sixty-four patients were evaluated. The mean age was 42.1 ± 3.2 years and the most prevalent disease was acute myeloid leukemia (39%). There was a high prevalence of gastrointestinal symptoms including nausea (100%), vomiting (97%) and mucositis (93%). Between admission and discharge there was a significant decrease in the median weight (−2.5 kg; 71.5 vs. 68.75 kg; p-value < 0.001), body mass index (−0.9 kg/m(2); 24.8 vs. 24.4 kg/m(2); p-value < 0.001), and serum albumin levels (−0.2 g/dL; 3.7 vs. 3.6 g/dL; p-value = 0.024). The survival time after hematopoietic stem cell transplantation correlated negatively with C-reactive protein at discharge (CC = −0.72; p-value < 0.001) and positively with serum albumin levels (CC = 0.56; p-value = 0.004) and with high total protein level at discharge (CC = 0.53; p-value = 0.006). CONCLUSION: Our results suggest that patients submitted to allogeneic hematopoietic stem cell transplantation have compromised nutritional status during the hospital stay for transplantation. Sociedade Brasileira de Hematologia e Hemoterapia 2014 2014-07-18 /pmc/articles/PMC4318470/ /pubmed/25453651 http://dx.doi.org/10.1016/j.bjhh.2014.07.014 Text en © 2014 Associac¸ão Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Original Article Ferreira, Érika Elias Guerra, Daiane Cristina Baluz, Kátia de Resende Furtado, Wander da Silva Bouzas, Luis Fernando Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study |
title | Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study |
title_full | Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study |
title_fullStr | Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study |
title_full_unstemmed | Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study |
title_short | Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study |
title_sort | nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318470/ https://www.ncbi.nlm.nih.gov/pubmed/25453651 http://dx.doi.org/10.1016/j.bjhh.2014.07.014 |
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