Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin

Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores via conformational transitions that remain to be structurally and mechanistic...

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Detalles Bibliográficos
Autores principales: Lukoyanova, Natalya, Kondos, Stephanie C., Farabella, Irene, Law, Ruby H. P., Reboul, Cyril F., Caradoc-Davies, Tom T., Spicer, Bradley A., Kleifeld, Oded, Traore, Daouda A. K., Ekkel, Susan M., Voskoboinik, Ilia, Trapani, Joseph A., Hatfaludi, Tamas, Oliver, Katherine, Hotze, Eileen M., Tweten, Rodney K., Whisstock, James C., Topf, Maya, Saibil, Helen R., Dunstone, Michelle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318580/
https://www.ncbi.nlm.nih.gov/pubmed/25654333
http://dx.doi.org/10.1371/journal.pbio.1002049

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