A Barcode-Free Combinatorial Screening Platform for Matrix Metalloproteinase Screening

[Image: see text] Application of droplet microfluidics to combinatorial screening applications remains elusive because of the need for composition-identifying unique barcodes. Here we propose a barcode-free continuous flow droplet microfluidic platform to suit the requirements of combinatorial scree...

Descripción completa

Detalles Bibliográficos
Autores principales: Rane, Tushar D., Zec, Helena C., Wang, Tza-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318618/
https://www.ncbi.nlm.nih.gov/pubmed/25543856
http://dx.doi.org/10.1021/ac504330x
_version_ 1782355867500281856
author Rane, Tushar D.
Zec, Helena C.
Wang, Tza-Huei
author_facet Rane, Tushar D.
Zec, Helena C.
Wang, Tza-Huei
author_sort Rane, Tushar D.
collection PubMed
description [Image: see text] Application of droplet microfluidics to combinatorial screening applications remains elusive because of the need for composition-identifying unique barcodes. Here we propose a barcode-free continuous flow droplet microfluidic platform to suit the requirements of combinatorial screening applications. We demonstrate robust and repeatable functioning of this platform with matrix metalloproteinase activity screening as a sample application.
format Online
Article
Text
id pubmed-4318618
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-43186182015-12-28 A Barcode-Free Combinatorial Screening Platform for Matrix Metalloproteinase Screening Rane, Tushar D. Zec, Helena C. Wang, Tza-Huei Anal Chem [Image: see text] Application of droplet microfluidics to combinatorial screening applications remains elusive because of the need for composition-identifying unique barcodes. Here we propose a barcode-free continuous flow droplet microfluidic platform to suit the requirements of combinatorial screening applications. We demonstrate robust and repeatable functioning of this platform with matrix metalloproteinase activity screening as a sample application. American Chemical Society 2014-12-28 2015-02-03 /pmc/articles/PMC4318618/ /pubmed/25543856 http://dx.doi.org/10.1021/ac504330x Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Rane, Tushar D.
Zec, Helena C.
Wang, Tza-Huei
A Barcode-Free Combinatorial Screening Platform for Matrix Metalloproteinase Screening
title A Barcode-Free Combinatorial Screening Platform for Matrix Metalloproteinase Screening
title_full A Barcode-Free Combinatorial Screening Platform for Matrix Metalloproteinase Screening
title_fullStr A Barcode-Free Combinatorial Screening Platform for Matrix Metalloproteinase Screening
title_full_unstemmed A Barcode-Free Combinatorial Screening Platform for Matrix Metalloproteinase Screening
title_short A Barcode-Free Combinatorial Screening Platform for Matrix Metalloproteinase Screening
title_sort barcode-free combinatorial screening platform for matrix metalloproteinase screening
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318618/
https://www.ncbi.nlm.nih.gov/pubmed/25543856
http://dx.doi.org/10.1021/ac504330x
work_keys_str_mv AT ranetushard abarcodefreecombinatorialscreeningplatformformatrixmetalloproteinasescreening
AT zechelenac abarcodefreecombinatorialscreeningplatformformatrixmetalloproteinasescreening
AT wangtzahuei abarcodefreecombinatorialscreeningplatformformatrixmetalloproteinasescreening
AT ranetushard barcodefreecombinatorialscreeningplatformformatrixmetalloproteinasescreening
AT zechelenac barcodefreecombinatorialscreeningplatformformatrixmetalloproteinasescreening
AT wangtzahuei barcodefreecombinatorialscreeningplatformformatrixmetalloproteinasescreening

Ejemplares similares