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Significant Accumulation of Polymyxin in Single Renal Tubular Cells: A Medicinal Chemistry and Triple Correlative Microscopy Approach

[Image: see text] Polymyxin is the last-line therapy against Gram-negative ‘superbugs’; however, dose-limiting nephrotoxicity can occur in up to 60% of patients after intravenous administration. Understanding the accumulation and concentration of polymyxin within renal tubular cells is essential for...

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Detalles Bibliográficos
Autores principales:	Azad, Mohammad A. K., Roberts, Kade D., Yu, Heidi H., Liu, Boyin, Schofield, Alice V., James, Simon A., Howard, Daryl L., Nation, Roger L., Rogers, Kelly, de Jonge, Martin D., Thompson, Philip E., Fu, Jing, Velkov, Tony, Li, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318625/ https://www.ncbi.nlm.nih.gov/pubmed/25553489 http://dx.doi.org/10.1021/ac504516k

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