The energy landscape of adenylate kinase during catalysis

Kinases perform phosphoryl-transfer reactions in milliseconds; without enzymes, these reactions would take about 8000 years under physiological conditions. Despite extensive studies, a comprehensive understanding of kinase energy landscapes, including both chemical and conformational steps, is lacki...

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Detalles Bibliográficos
Autores principales: Kerns, S. Jordan, Agafonov, Roman V., Cho, Young-Jin, Pontiggia, Francesco, Otten, Renee, Pachov, Dimitar V., Kutter, Steffen, Phung, Lien A., Murphy, Padraig N., Thai, Vu, Alber, Tom, Hagan, Michael F., Kern, Dorothee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318763/
https://www.ncbi.nlm.nih.gov/pubmed/25580578
http://dx.doi.org/10.1038/nsmb.2941

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