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Tetrameric Ctp1 coordinates DNA binding and bridging in DNA double strand break repair

Ctp1 (aka CtIP or Sae2) collaborates with Mre11–Rad50–Nbs1 to initiate repair of DNA double strand breaks (DSBs), but its function(s) remain enigmatic. We report that tetrameric Schizosaccharomyces pombe Ctp1 harbors multivalent DNA-binding and bridging activities. Through structural and biophysical...

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Detalles Bibliográficos
Autores principales:	Andres, Sara N., Appel, C. Denise, Westmoreland, Jim, Williams, Jessica S., Nguyen, Yvonne, Robertson, Patrick D., Resnick, Michael A., Williams, R. Scott
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318798/ https://www.ncbi.nlm.nih.gov/pubmed/25580577 http://dx.doi.org/10.1038/nsmb.2945

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