Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro

The tryptophan metabolite, kynurenic acid (KYNA), is a preferential antagonist of the α7 nicotinic acetylcholine receptor at endogenous brain concentrations. Recent studies have suggested that increase of brain KYNA levels is involved in psychiatric disorders such as schizophrenia and depression. KY...

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Detalles Bibliográficos
Autores principales: Sekine, Airi, Okamoto, Misaki, Kanatani, Yuka, Sano, Mitsue, Shibata, Katsumi, Fukuwatari, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318830/
https://www.ncbi.nlm.nih.gov/pubmed/25674503
http://dx.doi.org/10.1186/s40064-015-0826-9

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