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Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation

GDF8, or myostatin, is a member of the TGF-β superfamily of secreted polypeptide growth factors. GDF8 is a potent negative regulator of myogenesis both in vivo and in vitro. We found that GDF8 signaling was inhibited by the small molecule ATP competitive inhibitors dorsomorphin and LDN-193189. These...

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Detalles Bibliográficos
Autores principales:	Horbelt, Daniel, Boergermann, Jan H., Chaikuad, Apirat, Alfano, Ivan, Williams, Eleanor, Lukonin, Ilya, Timmel, Tobias, Bullock, Alex N., Knaus, Petra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319009/ https://www.ncbi.nlm.nih.gov/pubmed/25368322 http://dx.doi.org/10.1074/jbc.M114.604397

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