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Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases
Multiple factors have been shown to alter intestinal microbial diversity. It remains to be seen, however, how multiple collective pressures impact the activity in the gut environment and which, if any, is positioned as a dominant driving factor determining the final metabolic outcomes. Here, we desc...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319156/ https://www.ncbi.nlm.nih.gov/pubmed/25655524 http://dx.doi.org/10.1038/srep08310 |
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author | Rojo, David Hevia, Arancha Bargiela, Rafael López, Patricia Cuervo, Adriana González, Sonia Suárez, Ana Sánchez, Borja Martínez-Martínez, Mónica Milani, Christian Ventura, Marco Barbas, Coral Moya, Andrés Suárez, Antonio Margolles, Abelardo Ferrer, Manuel |
author_facet | Rojo, David Hevia, Arancha Bargiela, Rafael López, Patricia Cuervo, Adriana González, Sonia Suárez, Ana Sánchez, Borja Martínez-Martínez, Mónica Milani, Christian Ventura, Marco Barbas, Coral Moya, Andrés Suárez, Antonio Margolles, Abelardo Ferrer, Manuel |
author_sort | Rojo, David |
collection | PubMed |
description | Multiple factors have been shown to alter intestinal microbial diversity. It remains to be seen, however, how multiple collective pressures impact the activity in the gut environment and which, if any, is positioned as a dominant driving factor determining the final metabolic outcomes. Here, we describe the results of a metabolome-wide scan of gut microbiota in 18 subjects with systemic lupus erythematosus (SLE) and 17 healthy control subjects and demonstrate a statistically significant difference (p < 0.05) between the two groups. Healthy controls could be categorized (p < 0.05) based on their body mass index (BMI), whereas individuals with SLE could not. We discuss the prevalence of SLE compared with BMI as the dominant factor that regulates gastrointestinal microbial metabolism and provide plausible explanatory causes. Our results uncover novel perspectives with clinical relevance for human biology. In particular, we rank the importance of various pathophysiologies for gut homeostasis. |
format | Online Article Text |
id | pubmed-4319156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-43191562015-02-13 Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases Rojo, David Hevia, Arancha Bargiela, Rafael López, Patricia Cuervo, Adriana González, Sonia Suárez, Ana Sánchez, Borja Martínez-Martínez, Mónica Milani, Christian Ventura, Marco Barbas, Coral Moya, Andrés Suárez, Antonio Margolles, Abelardo Ferrer, Manuel Sci Rep Article Multiple factors have been shown to alter intestinal microbial diversity. It remains to be seen, however, how multiple collective pressures impact the activity in the gut environment and which, if any, is positioned as a dominant driving factor determining the final metabolic outcomes. Here, we describe the results of a metabolome-wide scan of gut microbiota in 18 subjects with systemic lupus erythematosus (SLE) and 17 healthy control subjects and demonstrate a statistically significant difference (p < 0.05) between the two groups. Healthy controls could be categorized (p < 0.05) based on their body mass index (BMI), whereas individuals with SLE could not. We discuss the prevalence of SLE compared with BMI as the dominant factor that regulates gastrointestinal microbial metabolism and provide plausible explanatory causes. Our results uncover novel perspectives with clinical relevance for human biology. In particular, we rank the importance of various pathophysiologies for gut homeostasis. Nature Publishing Group 2015-02-06 /pmc/articles/PMC4319156/ /pubmed/25655524 http://dx.doi.org/10.1038/srep08310 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Rojo, David Hevia, Arancha Bargiela, Rafael López, Patricia Cuervo, Adriana González, Sonia Suárez, Ana Sánchez, Borja Martínez-Martínez, Mónica Milani, Christian Ventura, Marco Barbas, Coral Moya, Andrés Suárez, Antonio Margolles, Abelardo Ferrer, Manuel Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases |
title | Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases |
title_full | Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases |
title_fullStr | Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases |
title_full_unstemmed | Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases |
title_short | Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases |
title_sort | ranking the impact of human health disorders on gut metabolism: systemic lupus erythematosus and obesity as study cases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319156/ https://www.ncbi.nlm.nih.gov/pubmed/25655524 http://dx.doi.org/10.1038/srep08310 |
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