Cargando…

Analysis of Major Genome Loci Underlying Artemisinin Resistance and pfmdr1 Copy Number in pre- and post-ACTs in Western Kenya

Genetic analysis of molecular markers is critical in tracking the emergence and/or spread of artemisinin resistant parasites. Clinical isolates collected in western Kenya pre- and post- introduction of artemisinin combination therapies (ACTs) were genotyped at SNP positions in regions of strong sele...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ngalah, Bidii S., Ingasia, Luiser A., Cheruiyot, Agnes C., Chebon, Lorna J., Juma, Dennis W., Muiruri, Peninah, Onyango, Irene, Ogony, Jack, Yeda, Redemptah A., Cheruiyot, Jelagat, Mbuba, Emmanuel, Mwangoka, Grace, Achieng, Angela O., Ng'ang'a, Zipporah, Andagalu, Ben, Akala, Hoseah M., Kamau, Edwin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319159/ https://www.ncbi.nlm.nih.gov/pubmed/25655315 http://dx.doi.org/10.1038/srep08308

Ejemplares similares

Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance (pfmdr1) gene in Kenya
por: Muiruri, Peninah, et al.
Publicado: (2018)

Genetically Determined Response to Artemisinin Treatment in Western Kenyan Plasmodium falciparum Parasites
por: Chebon, Lorna J., et al.
Publicado: (2016)

Trends in drug resistance codons in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Kenyan parasites from 2008 to 2012
por: Juma, Dennis W, et al.
Publicado: (2014)

Temporal trends in prevalence of Plasmodium falciparum molecular markers selected for by artemether–lumefantrine treatment in pre-ACT and post-ACT parasites in western Kenya
por: Achieng, Angela O., et al.
Publicado: (2015)

The Genotypic and Phenotypic Stability of Plasmodium falciparum Field Isolates in Continuous In Vitro Culture
por: Yeda, Redemptah, et al.
Publicado: (2016)

The Role of Pfmdr1 and Pfcrt in Changing Chloroquine, Amodiaquine, Mefloquine and Lumefantrine Susceptibility in Western-Kenya P. falciparum Samples during 2008–2011
por: Eyase, Fredrick L., et al.
Publicado: (2013)

Five-year tracking of Plasmodium falciparum allele frequencies in a holoendemic area with indistinct seasonal transitions
por: Akala, Hoseah M, et al.
Publicado: (2014)

Age-dependent antibody profiles to plasmodium antigens are differentially associated with two artemisinin combination therapy outcomes in high transmission setting
por: Andagalu, Ben, et al.
Publicado: (2022)

Malaria Transmission Dynamics in a High-Transmission Setting of Western Kenya and the Inadequate Treatment Response to Artemether-Lumefantrine in an Asymptomatic Population
por: Andagalu, Ben, et al.
Publicado: (2022)

A seven-year surveillance of epidemiology of malaria reveals travel and gender are the key drivers of dispersion of drug resistant genotypes in Kenya
por: Maraka, Moureen, et al.
Publicado: (2020)

Isoliensinine from Cissampelos pariera rhizomes exhibits potential gametocytocidal and anti-malarial activities against Plasmodium falciparum clinical isolates
por: Muema, Jackson M., et al.
Publicado: (2023)

Burden of malaria infection among individuals of varied blood groups in Kenya
por: Yeda, Redemptah, et al.
Publicado: (2022)

Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs
por: Wakoli, Dancan M., et al.
Publicado: (2022)

Target-similarity search using Plasmodium falciparum proteome identifies approved drugs with anti-malarial activity and their possible targets
por: Mogire, Reagan M., et al.
Publicado: (2017)

Synergism in Antiplasmodial Activities of Artemether and Lumefantrine in Combination with Securidaca longipedunculata Fresen (Polygalaceae)
por: Ochora, Douglas O., et al.
Publicado: (2021)

The role of complement immune response on artemisinin-based combination therapy in a population from malaria endemic region of Western Kenya
por: Wanjala, Christine N. L., et al.
Publicado: (2020)

Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya
por: Atilaw, Yoseph, et al.
Publicado: (2017)

Ex vivo and In vitro antiplasmodial activities of approved drugs predicted to have antimalarial activities using chemogenomics and drug repositioning approach
por: Ochora, Douglas O., et al.
Publicado: (2023)

Characterization of sulfated polysaccharide activity against virulent Plasmodium falciparum PHISTb/RLP1 protein
por: Mutisya, Jennifer M., et al.
Publicado: (2022)

Histomorphological changes in the common carotid artery of the male rat in induced hypogonadism
por: Cheruiyot, Isaac, et al.
Publicado: (2018)

The prevalence and antifolate drug resistance profiles of Plasmodium falciparum in study participants randomized to discontinue or continue cotrimoxazole prophylaxis
por: Juma, Dennis W., et al.
Publicado: (2019)

Comparison of Indoor Mosquito Collection Methods in the Assessment of Lymphatic Filariasis Transmission Dynamics in Mosquito Vectors in Tana River County, Kenya
por: Kinyatta, Nancy Mutanu, et al.
Publicado: (2018)

Potential for urban agriculture to support accessible and impactful undergraduate biology education
por: Kay, Adam D., et al.
Publicado: (2022)

Monitoring PfMDR1 transport in Plasmodium falciparum
por: Reiling, Sarah J, et al.
Publicado: (2015)

PfMDR2 and PfMDR5 are dispensable for Plasmodium falciparum asexual parasite multiplication but change in vitro susceptibility to anti-malarial drugs
por: van der Velden, Maarten, et al.
Publicado: (2015)

Epidemiological and clinical implications of asymptomatic malaria and schistosomiasis co-infections in a rural community in western Kenya
por: Kamau, Edwin, et al.
Publicado: (2021)

A Spatial Survival Model for Risk Factors of Under-Five Child Mortality in Kenya
por: Daniel, Kilemi, et al.
Publicado: (2021)

PfMDR1: Mechanisms of Transport Modulation by Functional Polymorphisms
por: Ferreira, Pedro Eduardo, et al.
Publicado: (2011)

PfMDR1 Transport Rates Assessed in Intact Isolated Plasmodium falciparum Digestive Vacuoles Reflect Functional Drug Resistance Relationship with pfmdr1 Mutations
por: Simon, Nina, et al.
Publicado: (2022)

Signatures of Selection in Admixed Dairy Cattle in Tanzania
por: Cheruiyot, Evans Kiptoo, et al.
Publicado: (2018)

Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline
por: Mogere, Edwin, et al.
Publicado: (2023)

Asymptomatic malaria infections and Pfmdr1 mutations in an endemic area of Nigeria
por: Dokunmu, Titilope M., et al.
Publicado: (2019)

In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin
por: Njokah, Muturi J., et al.
Publicado: (2016)

Prevalence of pfk13 and pfmdr1 polymorphisms in Bounkiling, Southern Senegal
por: Ahouidi, Ambroise, et al.
Publicado: (2021)

Factors associated with adequate weekly reporting for disease surveillance data among health facilities in Nairobi County, Kenya, 2013
por: Mwatondo, Athman Juma, et al.
Publicado: (2016)

Is there evidence of intra-uterine vertical transmission potential of COVID-19 infection in samples tested by quantitative RT-PCR?
por: Cheruiyot, Isaac, et al.
Publicado: (2020)

WCN23-0874 A CROSS-SECTIONAL STUDY OF THE PREVALENCE AND OUTCOMES OF ACUTE KIDNEY INJURY IN PATIENTS WITH COVID 19 AT A TERTIARY HOSPITAL IN NAIROBI
por: Cheruiyot, S., et al.
Publicado: (2023)

Longitudinal study on Plasmodium falciparum gametocyte carriage following artemether-lumefantrine administration in a cohort of children aged 12–47 months living in Western Kenya, a high transmission area
por: Andagalu, Ben, et al.
Publicado: (2014)

Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy
por: Duah, Nancy O, et al.
Publicado: (2013)

Distribution of pfmdr1 polymorphisms in Plasmodium falciparum isolated from Southern Thailand
por: Mungthin, Mathirut, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_4bvbt8vrouibru76eik7tbs5jp