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Radial extracorporeal shock wave treatment harms developing chicken embryos

Radial extracorporeal shock wave treatment (rESWT) has became one of the best investigated treatment modalities for cellulite, including the abdomen as a treatment site. Notably, pregnancy is considered a contraindication for rESWT, and concerns have been raised about possible harm to the embryo whe...

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Autores principales: Kiessling, Maren C., Milz, Stefan, Frank, Hans-Georg, Korbel, Rüdiger, Schmitz, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319177/
https://www.ncbi.nlm.nih.gov/pubmed/25655309
http://dx.doi.org/10.1038/srep08281
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author Kiessling, Maren C.
Milz, Stefan
Frank, Hans-Georg
Korbel, Rüdiger
Schmitz, Christoph
author_facet Kiessling, Maren C.
Milz, Stefan
Frank, Hans-Georg
Korbel, Rüdiger
Schmitz, Christoph
author_sort Kiessling, Maren C.
collection PubMed
description Radial extracorporeal shock wave treatment (rESWT) has became one of the best investigated treatment modalities for cellulite, including the abdomen as a treatment site. Notably, pregnancy is considered a contraindication for rESWT, and concerns have been raised about possible harm to the embryo when a woman treated with rESWT for cellulite is not aware of her pregnancy. Here we tested the hypothesis that rESWT may cause serious physical harm to embryos. To this end, chicken embryos were exposed in ovo to various doses of radial shock waves on either day 3 or day 4 of development, resembling the developmental stage of four- to six-week-old human embryos. We found a dose-dependent increase in the number of embryos that died after radial shock wave exposure on either day 3 or day 4 of development. Among the embryos that survived the shock wave exposure a few showed severe congenital defects such as missing eyes. Evidently, our data cannot directly be used to draw conclusions about potential harm to the embryo of a pregnant woman treated for cellulite with rESWT. However, to avoid any risks we strongly recommend applying radial shock waves in the treatment of cellulite only if a pregnancy is ruled out.
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spelling pubmed-43191772015-02-13 Radial extracorporeal shock wave treatment harms developing chicken embryos Kiessling, Maren C. Milz, Stefan Frank, Hans-Georg Korbel, Rüdiger Schmitz, Christoph Sci Rep Article Radial extracorporeal shock wave treatment (rESWT) has became one of the best investigated treatment modalities for cellulite, including the abdomen as a treatment site. Notably, pregnancy is considered a contraindication for rESWT, and concerns have been raised about possible harm to the embryo when a woman treated with rESWT for cellulite is not aware of her pregnancy. Here we tested the hypothesis that rESWT may cause serious physical harm to embryos. To this end, chicken embryos were exposed in ovo to various doses of radial shock waves on either day 3 or day 4 of development, resembling the developmental stage of four- to six-week-old human embryos. We found a dose-dependent increase in the number of embryos that died after radial shock wave exposure on either day 3 or day 4 of development. Among the embryos that survived the shock wave exposure a few showed severe congenital defects such as missing eyes. Evidently, our data cannot directly be used to draw conclusions about potential harm to the embryo of a pregnant woman treated for cellulite with rESWT. However, to avoid any risks we strongly recommend applying radial shock waves in the treatment of cellulite only if a pregnancy is ruled out. Nature Publishing Group 2015-02-06 /pmc/articles/PMC4319177/ /pubmed/25655309 http://dx.doi.org/10.1038/srep08281 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Kiessling, Maren C.
Milz, Stefan
Frank, Hans-Georg
Korbel, Rüdiger
Schmitz, Christoph
Radial extracorporeal shock wave treatment harms developing chicken embryos
title Radial extracorporeal shock wave treatment harms developing chicken embryos
title_full Radial extracorporeal shock wave treatment harms developing chicken embryos
title_fullStr Radial extracorporeal shock wave treatment harms developing chicken embryos
title_full_unstemmed Radial extracorporeal shock wave treatment harms developing chicken embryos
title_short Radial extracorporeal shock wave treatment harms developing chicken embryos
title_sort radial extracorporeal shock wave treatment harms developing chicken embryos
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319177/
https://www.ncbi.nlm.nih.gov/pubmed/25655309
http://dx.doi.org/10.1038/srep08281
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