Cargando…

Phosphodiesterase-4 inhibition with rolipram attenuates hepatocellular injury in hyperinflammation in vivo and in vitro without influencing inflammation and HO-1 expression

OBJECTIVE: To investigate the impact of the phophodiesterase-4 inhibition (PD-4-I) with rolipram on hepatic integrity in lipopolysaccharide (LPS) induced hyperinflammation. MATERIALS AND METHODS: Liver microcirculation in rats was obtained using intravital microscopy. Macrohemodynamic parameters, bl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wollborn, Jakob, Wunder, Christian, Stix, Jana, Neuhaus, Winfried, Bruno, Rapahel R., Baar, Wolfgang, Flemming, Sven, Roewer, Norbert, Schlegel, Nicolas, Schick, Martin A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319242/ https://www.ncbi.nlm.nih.gov/pubmed/25709347 http://dx.doi.org/10.4103/0976-500X.149138

Ejemplares similares

Balanced Hydroxyethylstarch (HES 130/0.4) Impairs Kidney Function In-Vivo without Inflammation
por: Schick, Martin Alexander, et al.
Publicado: (2015)

Sepsis-induced acute kidney injury by standardized colon ascendens stent peritonitis in rats - a simple, reproducible animal model
por: Schick, Martin A, et al.
Publicado: (2014)

Rolipram: Eotaxin and phosphodiesterase IV inhibitor versus bronchial hyper-reactivity response
por: Khan, Hamza Hassan, et al.
Publicado: (2015)

Phosphodiesterase Type 4 Inhibitor Rolipram Improves Survival of Spiral Ganglion Neurons In Vitro
por: Kranz, Katharina, et al.
Publicado: (2014)

Effect of phosphodiesterase‐4 inhibitor rolipram on colonic hypermotility in water avoidance stress rat model
por: Yuan, FangTing, et al.
Publicado: (2022)

Rolipram, a Phosphodiesterase 4 Inhibitor, Stimulates Inducible cAMP Early Repressor Expression in Osteoblasts
por: Cho, Eun Sook, et al.
Publicado: (2005)

Clinical Implication of Phosphodiesterase-4-Inhibition
por: Schick, Martin Alexander, et al.
Publicado: (2022)

The Role of Butyrate in Attenuating Pathobiont-Induced Hyperinflammation
por: Chen, Jiezhong, et al.
Publicado: (2020)

In Situ Neutralization and Detoxification of LPS to Attenuate Hyperinflammation
por: Li, Xiaoyu, et al.
Publicado: (2023)

Effects of crystalloids and colloids on liver and intestine microcirculation and function in cecal ligation and puncture induced septic rodents
por: Schick, Martin Alexander, et al.
Publicado: (2012)

Attenuating hyperinflammation in COVID-19: A change in paradigm?
por: Molnar, Zsolt, et al.
Publicado: (2020)

A nanotrap improves survival in severe sepsis by attenuating hyperinflammation
por: Shi, Changying, et al.
Publicado: (2020)

Effect of rolipram, a phosphodiesterase enzyme type–4 inhibitor, on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress
por: Shalaby, Amany Mohamed, et al.
Publicado: (2012)

Novel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis
por: Gobejishvili, Leila, et al.
Publicado: (2022)

Hyperinflammation, T cells, and endotoxemia
por: Inoue, Makoto, et al.
Publicado: (2015)

Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 (PDE4) inhibitor rolipram on behavior depend on cyclic AMP-response element binding protein (CREB)-mediated neurogenesis in the hippocampus
por: Li, Yun-Feng, et al.
Publicado: (2009)

In Situ Neutralization and Detoxification of LPS to Attenuate Hyperinflammation (Adv. Sci. 26/2023)
por: Li, Xiaoyu, et al.
Publicado: (2023)

Comparison of hydroxyethylstarch (HES 130/0.4) and 5% human albumin for volume substitution in pediatric neurosurgery: A retrospective, single center study
por: Schick, Martin A., et al.
Publicado: (2021)

Hydroxyethylstarch revisited for acute brain injury treatment
por: Schick, Martin A., et al.
Publicado: (2020)

The combination of rolipram and cilostamide improved the developmental competence of cloned porcine embryos
por: Tanga, Bereket Molla, et al.
Publicado: (2023)

Rolipram, a Selective Phosphodiesterase 4 Inhibitor, Ameliorates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain through Inhibition of Inflammatory Cytokines in the Dorsal Root Ganglion
por: Kim, Hee Kee, et al.
Publicado: (2017)

Immunopathology of Hyperinflammation in COVID-19
por: Gustine, Joshua N., et al.
Publicado: (2021)

High-dose intravenous vitamin C attenuates hyperinflammation in severe coronavirus disease 2019
por: Xia, Guozhi, et al.
Publicado: (2021)

Protective Effect of Administered Rolipram against Radiation-Induced Testicular Injury in Mice
por: Lee, Wan, et al.
Publicado: (2015)

Kawasaki-Erkrankung oder Hyperinflammations-Syndrom?
Publicado: (2020)

Kawasaki-Erkrankung oder Hyperinflammations-Syndrom?
por: -, -
Publicado: (2020)

Management of hyperinflammation in COVID-19 patients
por: Suberviola, Borja, et al.
Publicado: (2022)

Rolipram Improves Outcome in a Rat Model of Infant Sepsis-Induced Cardiorenal Syndrome
por: Sims, Clark R., et al.
Publicado: (2017)

Reversing Alzheimer's disease dementia with clemastine, fingolimod, or rolipram, plus anti‐amyloid therapy
por: Fessel, Jeffrey
Publicado: (2022)

Microdialysis and ultrasound elastography for monitoring of localized muscular reaction after pharmacological stimulation in rats
por: Johannsen, Stephan, et al.
Publicado: (2018)

Current Concepts of Hyperinflammation in Chronic Granulomatous Disease
por: Rieber, Nikolaus, et al.
Publicado: (2012)

COVID-19 Hyperinflammation: What about Neutrophils?
por: Didangelos, Athanasios
Publicado: (2020)

Frontal encephalopathy related to hyperinflammation in COVID-19
por: Cani, Ilaria, et al.
Publicado: (2020)

Delving beneath the surface of hyperinflammation in COVID-19
por: Reddy, Kiran, et al.
Publicado: (2020)

Hyperinflammation with COVID-19: The key to patient deterioration?()()
por: Haigh, Kathryn, et al.
Publicado: (2020)

Post-COVID-19 arthritis: is it hyperinflammation or autoimmunity?
por: Taha, Sara Ibrahim, et al.
Publicado: (2022)

Chasing the Ghost: Hyperinflammation Does Not Cause Sepsis
por: Shapiro, Leland, et al.
Publicado: (2022)

Fostering experimental and computational synergy to modulate hyperinflammation
por: Potapov, Ilya, et al.
Publicado: (2022)

A remission spectroscopy system for in vivo monitoring of hemoglobin oxygen saturation in murine hepatic sinusoids, in early systemic inflammation
por: Wunder, Christian, et al.
Publicado: (2005)

Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques
por: Rutten, K., et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_082omrjabdmhd3cl9p6f2tvqri