Clinically relevant fluoroquinolone resistance due to constitutive overexpression of the PatAB ABC transporter in Streptococcus pneumoniae is conferred by disruption of a transcriptional attenuator

OBJECTIVES: Constitutive overexpression of patAB has been observed in several unrelated fluoroquinolone-resistant laboratory mutants and clinical isolates; therefore, we sought to identify the cause of this overexpression. METHODS: Constitutive patAB overexpression in two clinical isolates and a lab...

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Detalles Bibliográficos
Autores principales: Baylay, Alison J., Piddock, Laura J. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319486/
https://www.ncbi.nlm.nih.gov/pubmed/25411187
http://dx.doi.org/10.1093/jac/dku449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319486/
https://www.ncbi.nlm.nih.gov/pubmed/25411187
http://dx.doi.org/10.1093/jac/dku449

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