Draft Genome Sequence of Marine Bacterium Streptomyces sp. Strain CNQ431, a Producer of the Cytokine Inhibitor Splenocin

Currently, corticosteroids are the most potent anti-inflammatory drugs on the market. Here, we announce the draft genome sequence of the marine-derived Streptomyces sp. strain CNQ431, which produces cytokine inhibitors, termed splenocins, which display potent suppression of cytokine production at a...

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Detalles Bibliográficos
Autores principales: Yu, Mingjia, Dai, Zheng, Qu, Xudong, Gao, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Prokaryotes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319611/
https://www.ncbi.nlm.nih.gov/pubmed/25614558
http://dx.doi.org/10.1128/genomeA.01383-14
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author Yu, Mingjia
Dai, Zheng
Qu, Xudong
Gao, Xu
author_facet Yu, Mingjia
Dai, Zheng
Qu, Xudong
Gao, Xu
author_sort Yu, Mingjia
collection PubMed
description Currently, corticosteroids are the most potent anti-inflammatory drugs on the market. Here, we announce the draft genome sequence of the marine-derived Streptomyces sp. strain CNQ431, which produces cytokine inhibitors, termed splenocins, which display potent suppression of cytokine production at a comparable level to that of corticosteroids. The genome is approximately 498,750 bp with 72.03% G+C content.
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spelling pubmed-43196112015-02-24 Draft Genome Sequence of Marine Bacterium Streptomyces sp. Strain CNQ431, a Producer of the Cytokine Inhibitor Splenocin Yu, Mingjia Dai, Zheng Qu, Xudong Gao, Xu Genome Announc Prokaryotes Currently, corticosteroids are the most potent anti-inflammatory drugs on the market. Here, we announce the draft genome sequence of the marine-derived Streptomyces sp. strain CNQ431, which produces cytokine inhibitors, termed splenocins, which display potent suppression of cytokine production at a comparable level to that of corticosteroids. The genome is approximately 498,750 bp with 72.03% G+C content. American Society for Microbiology 2015-01-22 /pmc/articles/PMC4319611/ /pubmed/25614558 http://dx.doi.org/10.1128/genomeA.01383-14 Text en Copyright © 2015 Yu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Prokaryotes
Yu, Mingjia
Dai, Zheng
Qu, Xudong
Gao, Xu
Draft Genome Sequence of Marine Bacterium Streptomyces sp. Strain CNQ431, a Producer of the Cytokine Inhibitor Splenocin
title Draft Genome Sequence of Marine Bacterium Streptomyces sp. Strain CNQ431, a Producer of the Cytokine Inhibitor Splenocin
title_full Draft Genome Sequence of Marine Bacterium Streptomyces sp. Strain CNQ431, a Producer of the Cytokine Inhibitor Splenocin
title_fullStr Draft Genome Sequence of Marine Bacterium Streptomyces sp. Strain CNQ431, a Producer of the Cytokine Inhibitor Splenocin
title_full_unstemmed Draft Genome Sequence of Marine Bacterium Streptomyces sp. Strain CNQ431, a Producer of the Cytokine Inhibitor Splenocin
title_short Draft Genome Sequence of Marine Bacterium Streptomyces sp. Strain CNQ431, a Producer of the Cytokine Inhibitor Splenocin
title_sort draft genome sequence of marine bacterium streptomyces sp. strain cnq431, a producer of the cytokine inhibitor splenocin
topic Prokaryotes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319611/
https://www.ncbi.nlm.nih.gov/pubmed/25614558
http://dx.doi.org/10.1128/genomeA.01383-14
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