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Self-Immolative Polycations as Gene Delivery Vectors and Prodrugs Targeting Polyamine Metabolism in Cancer

[Image: see text] Polycations are explored as carriers to deliver therapeutic nucleic acids. Polycations are conventionally pharmacological inert with the sole function of delivering therapeutic cargo. This study reports synthesis of a self-immolative polycation (DSS-BEN) based on a polyamine analog...

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Detalles Bibliográficos
Autores principales:	Zhu, Yu, Li, Jing, Kanvinde, Shrey, Lin, Zhiyi, Hazeldine, Stuart, Singh, Rakesh K., Oupický, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319695/ https://www.ncbi.nlm.nih.gov/pubmed/25153488 http://dx.doi.org/10.1021/mp500469n

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