Upregulation of miR21 and Repression of Grhl3 by Leptin Mediates Sinusoidal Endothelial Injury in Experimental Nonalcoholic Steatohepatitis

Sinusoidal endothelial dysfunction (SED) has been found to be an early event in nonalcoholic steatohepatitis (NASH) progression but the molecular mechanisms underlying its causation remains elusive. We hypothesized that adipokine leptin worsens sinusoidal injury by decreasing functionally active nit...

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Detalles Bibliográficos
Autores principales: Pourhoseini, Sahar, Seth, Ratanesh Kumar, Das, Suvarthi, Dattaroy, Diptadip, Kadiiska, Maria B., Xie, Guanhua, Michelotti, Gregory A., Nagarkatti, Mitzi, Diehl, Anna Mae, Chatterjee, Saurabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319738/
https://www.ncbi.nlm.nih.gov/pubmed/25658689
http://dx.doi.org/10.1371/journal.pone.0116780

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