HLA-A*33:01 as Protective Allele for Severe Dengue in a Population of Filipino Children

Dengue virus infection is a leading cause of morbidity among children in the Philippines in recent years. In order to investigate the association of HLA Class I and II alleles and dengue disease severity in a cohort of Filipino children, we performed a case control study in 2 hospitals in Metro Mani...

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Detalles Bibliográficos
Autores principales: Mercado, Edelwisa Segubre, Espino, Fe Esperanza, Perez, Ma. Lucila M., Bilar, Josie M., Bajaro, Jemimah Dawn P., Huy, Nguyen Tien, Baello, Benilda Q, Kikuchi, Mihoko, Hirayama, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319754/
https://www.ncbi.nlm.nih.gov/pubmed/25659158
http://dx.doi.org/10.1371/journal.pone.0115619
Descripción
Sumario:Dengue virus infection is a leading cause of morbidity among children in the Philippines in recent years. In order to investigate the association of HLA Class I and II alleles and dengue disease severity in a cohort of Filipino children, we performed a case control study in 2 hospitals in Metro Manila from June 2008 to December 2009. A total of 250 laboratory confirmed dengue patients and 300 healthy individuals aged 5 to 15 years old were typed for HLA-A, B and DRB1 alleles. The frequency of HLA-A*33:01 was significantly decreased in severe dengue (DHF/ DSS; Pc = 0.0016)) and DSS (Pc = 0.0032) compared to the background population. These findings support a previous study that this allele may confer protection against the severe form of dengue and provide the first evidence of HLA association with dengue in the Philippines. Future studies should be directed in investigating the possible mechanisms of protection.

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