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Normal Range of Hepatic Fat Fraction on Dual- and Triple-Echo Fat Quantification MR in Children
OBJECTIVES: To evaluate hepatic fat fraction on dual- and triple-echo gradient-recalled echo MRI sequences in healthy children. MATERIALS AND METHODS: We retrospectively reviewed the records of children in a medical check-up clinic from May 2012 to November 2013. We excluded children with abnormal l...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319769/ https://www.ncbi.nlm.nih.gov/pubmed/25659155 http://dx.doi.org/10.1371/journal.pone.0117480 |
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author | Shin, Hyun Joo Kim, Hyun Gi Kim, Myung-Joon Koh, Hong Kim, Ha Yan Roh, Yun Ho Lee, Mi-Jung |
author_facet | Shin, Hyun Joo Kim, Hyun Gi Kim, Myung-Joon Koh, Hong Kim, Ha Yan Roh, Yun Ho Lee, Mi-Jung |
author_sort | Shin, Hyun Joo |
collection | PubMed |
description | OBJECTIVES: To evaluate hepatic fat fraction on dual- and triple-echo gradient-recalled echo MRI sequences in healthy children. MATERIALS AND METHODS: We retrospectively reviewed the records of children in a medical check-up clinic from May 2012 to November 2013. We excluded children with abnormal laboratory findings or those who were overweight. Hepatic fat fraction was measured on dual- and triple-echo sequences using 3T MRI. We compared fat fractions using the Wilcoxon signed rank test and the Bland-Altman 95% limits of agreement. The correlation between fat fractions and clinical and laboratory findings was evaluated using Spearman’s correlation test, and the cut-off values of fat fractions for diagnosing fatty liver were obtained from reference intervals. RESULTS: In 54 children (M:F = 26:28; 5–15 years; mean 9 years), the dual fat fraction (0.1–8.0%; median 1.6%) was not different from the triple fat fraction (0.4–6.5%; median 2.7%) (p = 0.010). The dual- and triple-echo fat fractions showed good agreement using a Bland-Altman plot (-0.6 ± 2.8%). Eight children (14.8%) on dual-echo sequences and six (11.1%) on triple-echo sequences had greater than 5% fat fraction. From these children, six out of eight children on dual-echo sequences and four out of six children on triple-echo sequences had a 5–6% hepatic fat fraction. When using a cut-off value of a 6% fat fraction derived from a reference interval, only 3.7% of children were diagnosed with fatty liver. There was no significant correlation between clinical and laboratory findings with dual and triple-echo fat fractions. CONCLUSIONS: Dual fat fraction was not different from triple fat fraction. We suggest a cut-off value of a 6% fat fraction is more appropriate for diagnosing fatty liver on both dual- and triple-echo sequences in children. |
format | Online Article Text |
id | pubmed-4319769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43197692015-02-18 Normal Range of Hepatic Fat Fraction on Dual- and Triple-Echo Fat Quantification MR in Children Shin, Hyun Joo Kim, Hyun Gi Kim, Myung-Joon Koh, Hong Kim, Ha Yan Roh, Yun Ho Lee, Mi-Jung PLoS One Research Article OBJECTIVES: To evaluate hepatic fat fraction on dual- and triple-echo gradient-recalled echo MRI sequences in healthy children. MATERIALS AND METHODS: We retrospectively reviewed the records of children in a medical check-up clinic from May 2012 to November 2013. We excluded children with abnormal laboratory findings or those who were overweight. Hepatic fat fraction was measured on dual- and triple-echo sequences using 3T MRI. We compared fat fractions using the Wilcoxon signed rank test and the Bland-Altman 95% limits of agreement. The correlation between fat fractions and clinical and laboratory findings was evaluated using Spearman’s correlation test, and the cut-off values of fat fractions for diagnosing fatty liver were obtained from reference intervals. RESULTS: In 54 children (M:F = 26:28; 5–15 years; mean 9 years), the dual fat fraction (0.1–8.0%; median 1.6%) was not different from the triple fat fraction (0.4–6.5%; median 2.7%) (p = 0.010). The dual- and triple-echo fat fractions showed good agreement using a Bland-Altman plot (-0.6 ± 2.8%). Eight children (14.8%) on dual-echo sequences and six (11.1%) on triple-echo sequences had greater than 5% fat fraction. From these children, six out of eight children on dual-echo sequences and four out of six children on triple-echo sequences had a 5–6% hepatic fat fraction. When using a cut-off value of a 6% fat fraction derived from a reference interval, only 3.7% of children were diagnosed with fatty liver. There was no significant correlation between clinical and laboratory findings with dual and triple-echo fat fractions. CONCLUSIONS: Dual fat fraction was not different from triple fat fraction. We suggest a cut-off value of a 6% fat fraction is more appropriate for diagnosing fatty liver on both dual- and triple-echo sequences in children. Public Library of Science 2015-02-06 /pmc/articles/PMC4319769/ /pubmed/25659155 http://dx.doi.org/10.1371/journal.pone.0117480 Text en © 2015 Shin et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Shin, Hyun Joo Kim, Hyun Gi Kim, Myung-Joon Koh, Hong Kim, Ha Yan Roh, Yun Ho Lee, Mi-Jung Normal Range of Hepatic Fat Fraction on Dual- and Triple-Echo Fat Quantification MR in Children |
title | Normal Range of Hepatic Fat Fraction on Dual- and Triple-Echo Fat Quantification MR in Children |
title_full | Normal Range of Hepatic Fat Fraction on Dual- and Triple-Echo Fat Quantification MR in Children |
title_fullStr | Normal Range of Hepatic Fat Fraction on Dual- and Triple-Echo Fat Quantification MR in Children |
title_full_unstemmed | Normal Range of Hepatic Fat Fraction on Dual- and Triple-Echo Fat Quantification MR in Children |
title_short | Normal Range of Hepatic Fat Fraction on Dual- and Triple-Echo Fat Quantification MR in Children |
title_sort | normal range of hepatic fat fraction on dual- and triple-echo fat quantification mr in children |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319769/ https://www.ncbi.nlm.nih.gov/pubmed/25659155 http://dx.doi.org/10.1371/journal.pone.0117480 |
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