Modeling of the Human Alveolar Rhabdomyosarcoma Pax3-Foxo1 Chromosome Translocation in Mouse Myoblasts Using CRISPR-Cas9 Nuclease

Many recurrent chromosome translocations in cancer result in the generation of fusion genes that are directly implicated in the tumorigenic process. Precise modeling of the effects of cancer fusion genes in mice has been inaccurate, as constructs of fusion genes often completely or partially lack th...

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Detalles Bibliográficos
Autores principales: Lagutina, Irina V., Valentine, Virginia, Picchione, Fabrizio, Harwood, Frank, Valentine, Marcus B., Villarejo-Balcells, Barbara, Carvajal, Jaime J., Grosveld, Gerard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319822/
https://www.ncbi.nlm.nih.gov/pubmed/25659124
http://dx.doi.org/10.1371/journal.pgen.1004951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319822/
https://www.ncbi.nlm.nih.gov/pubmed/25659124
http://dx.doi.org/10.1371/journal.pgen.1004951

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