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Potent Natural Soluble Epoxide Hydrolase Inhibitors from Pentadiplandra brazzeana Baillon: Synthesis, Quantification, and Measurement of Biological Activities In Vitro and In Vivo

We describe here three urea-based soluble epoxide hydrolase (sEH) inhibitors from the root of the plant Pentadiplandra brazzeana. The concentration of these ureas in the root was quantified by LC-MS/MS, showing that 1, 3-bis (4-methoxybenzyl) urea (MMU) is the most abundant (42.3 μg/g dry root weigh...

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Detalles Bibliográficos
Autores principales:	Kitamura, Seiya, Morisseau, Christophe, Inceoglu, Bora, Kamita, Shizuo G., De Nicola, Gina R., Nyegue, Maximilienne, Hammock, Bruce D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319826/ https://www.ncbi.nlm.nih.gov/pubmed/25659109 http://dx.doi.org/10.1371/journal.pone.0117438

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