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Hippocampal Subfield Volumes in First Episode and Chronic Schizophrenia

BACKGROUND: Reduced hippocampal volume in schizophrenia is a well-replicated finding. New imaging techniques allow delineation of hippocampal subfield volumes. Studies including predominantly chronic patients demonstrate differences between subfields in sensitivity to illness, and in associations wi...

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Autores principales: Kawano, Mitsuhiko, Sawada, Ken, Shimodera, Shinji, Ogawa, Yasuhiro, Kariya, Shinji, Lang, Donna J., Inoue, Shimpei, Honer, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319836/
https://www.ncbi.nlm.nih.gov/pubmed/25658118
http://dx.doi.org/10.1371/journal.pone.0117785
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author Kawano, Mitsuhiko
Sawada, Ken
Shimodera, Shinji
Ogawa, Yasuhiro
Kariya, Shinji
Lang, Donna J.
Inoue, Shimpei
Honer, William G.
author_facet Kawano, Mitsuhiko
Sawada, Ken
Shimodera, Shinji
Ogawa, Yasuhiro
Kariya, Shinji
Lang, Donna J.
Inoue, Shimpei
Honer, William G.
author_sort Kawano, Mitsuhiko
collection PubMed
description BACKGROUND: Reduced hippocampal volume in schizophrenia is a well-replicated finding. New imaging techniques allow delineation of hippocampal subfield volumes. Studies including predominantly chronic patients demonstrate differences between subfields in sensitivity to illness, and in associations with clinical features. We carried out a cross-sectional and longitudinal study of first episode, sub-chronic, and chronic patients, using an imaging strategy that allows for the assessment of multiple hippocampal subfields. METHODS: Hippocampal subfield volumes were measured in 34 patients with schizophrenia (19 first episode, 6 sub-chronic, 9 chronic) and 15 healthy comparison participants. A subset of 10 first episode and 12 healthy participants were rescanned after six months. RESULTS: Total left hippocampal volume was smaller in sub-chronic (p = 0.04, effect size 1.12) and chronic (p = 0.009, effect size 1.42) patients compared with healthy volunteers. The CA2-3 subfield volume of chronic patients was significantly decreased (p = 0.009, effect size 1.42) compared to healthy volunteers. The CA4-DG volume was significantly reduced in all three patient groups compared to healthy group (all p < 0.005). The two affected subfield volumes were inversely correlated with severity of negative symptoms (p < 0.05). There was a small, but statistically significant decline in left CA4-DG volume over the first six months of illness (p = 0.01). CONCLUSIONS: Imaging strategies defining the subfields of the hippocampus may be informative in linking symptoms and structural abnormalities, and in understanding more about progression during the early phases of illness in schizophrenia.
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spelling pubmed-43198362015-02-18 Hippocampal Subfield Volumes in First Episode and Chronic Schizophrenia Kawano, Mitsuhiko Sawada, Ken Shimodera, Shinji Ogawa, Yasuhiro Kariya, Shinji Lang, Donna J. Inoue, Shimpei Honer, William G. PLoS One Research Article BACKGROUND: Reduced hippocampal volume in schizophrenia is a well-replicated finding. New imaging techniques allow delineation of hippocampal subfield volumes. Studies including predominantly chronic patients demonstrate differences between subfields in sensitivity to illness, and in associations with clinical features. We carried out a cross-sectional and longitudinal study of first episode, sub-chronic, and chronic patients, using an imaging strategy that allows for the assessment of multiple hippocampal subfields. METHODS: Hippocampal subfield volumes were measured in 34 patients with schizophrenia (19 first episode, 6 sub-chronic, 9 chronic) and 15 healthy comparison participants. A subset of 10 first episode and 12 healthy participants were rescanned after six months. RESULTS: Total left hippocampal volume was smaller in sub-chronic (p = 0.04, effect size 1.12) and chronic (p = 0.009, effect size 1.42) patients compared with healthy volunteers. The CA2-3 subfield volume of chronic patients was significantly decreased (p = 0.009, effect size 1.42) compared to healthy volunteers. The CA4-DG volume was significantly reduced in all three patient groups compared to healthy group (all p < 0.005). The two affected subfield volumes were inversely correlated with severity of negative symptoms (p < 0.05). There was a small, but statistically significant decline in left CA4-DG volume over the first six months of illness (p = 0.01). CONCLUSIONS: Imaging strategies defining the subfields of the hippocampus may be informative in linking symptoms and structural abnormalities, and in understanding more about progression during the early phases of illness in schizophrenia. Public Library of Science 2015-02-06 /pmc/articles/PMC4319836/ /pubmed/25658118 http://dx.doi.org/10.1371/journal.pone.0117785 Text en © 2015 Kawano et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kawano, Mitsuhiko
Sawada, Ken
Shimodera, Shinji
Ogawa, Yasuhiro
Kariya, Shinji
Lang, Donna J.
Inoue, Shimpei
Honer, William G.
Hippocampal Subfield Volumes in First Episode and Chronic Schizophrenia
title Hippocampal Subfield Volumes in First Episode and Chronic Schizophrenia
title_full Hippocampal Subfield Volumes in First Episode and Chronic Schizophrenia
title_fullStr Hippocampal Subfield Volumes in First Episode and Chronic Schizophrenia
title_full_unstemmed Hippocampal Subfield Volumes in First Episode and Chronic Schizophrenia
title_short Hippocampal Subfield Volumes in First Episode and Chronic Schizophrenia
title_sort hippocampal subfield volumes in first episode and chronic schizophrenia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319836/
https://www.ncbi.nlm.nih.gov/pubmed/25658118
http://dx.doi.org/10.1371/journal.pone.0117785
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