Targeting Protein-Protein Interactions with Trimeric Ligands: High Affinity Inhibitors of the MAGUK Protein Family

PDZ domains in general, and those of PSD-95 in particular, are emerging as promising drug targets for diseases such as ischemic stroke. We have previously shown that dimeric ligands that simultaneously target PDZ1 and PDZ2 of PSD-95 are highly potent inhibitors of PSD-95. However, PSD-95 and the rel...

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Detalles Bibliográficos
Autores principales: Nissen, Klaus B., Haugaard-Kedström, Linda M., Wilbek, Theis S., Nielsen, Line S., Åberg, Emma, Kristensen, Anders S., Bach, Anders, Jemth, Per, Strømgaard, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319893/
https://www.ncbi.nlm.nih.gov/pubmed/25658767
http://dx.doi.org/10.1371/journal.pone.0117668

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