Anti-Human α-Synuclein N-Terminal Peptide Antibody Protects against Dopaminergic Cell Death and Ameliorates Behavioral Deficits in an AAV-α-Synuclein Rat Model of Parkinson’s Disease

The protein α-synuclein (α-Syn) has a central role in the pathogenesis of Parkinson’s disease (PD) and immunotherapeutic approaches targeting this molecule have shown promising results. In this study, novel antibodies were generated against specific peptides from full length human α-Syn and evaluate...

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Detalles Bibliográficos
Autores principales: Shahaduzzaman, Md, Nash, Kevin, Hudson, Charles, Sharif, Masroor, Grimmig, Bethany, Lin, Xiaoyang, Bai, Ge, Liu, Hui, Ugen, Kenneth E., Cao, Chuanhai, Bickford, Paula C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319932/
https://www.ncbi.nlm.nih.gov/pubmed/25658425
http://dx.doi.org/10.1371/journal.pone.0116841

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