PE859, a Novel Tau Aggregation Inhibitor, Reduces Aggregated Tau and Prevents Onset and Progression of Neural Dysfunction In Vivo

In tauopathies, a neural microtubule-associated protein tau (MAPT) is abnormally aggregated and forms neurofibrillary tangle. Therefore, inhibition of the tau aggregation is one of the key approaches for the treatment of these diseases. Here, we have identified a novel tau aggregation inhibitor, PE8...

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Detalles Bibliográficos
Autores principales: Okuda, Michiaki, Hijikuro, Ichiro, Fujita, Yuki, Wu, Xiaofeng, Nakayama, Shinichi, Sakata, Yoko, Noguchi, Yuji, Ogo, Makoto, Akasofu, Shigeru, Ito, Yoshimasa, Soeda, Yoshiyuki, Tsuchiya, Nobuhiko, Tanaka, Naoki, Takahashi, Takashi, Sugimoto, Hachiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319983/
https://www.ncbi.nlm.nih.gov/pubmed/25659102
http://dx.doi.org/10.1371/journal.pone.0117511

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