A B cell follicle sanctuary permits persistent productive SIV infection in elite controllers

Chronic phase HIV/SIV replication is reduced by as much as 10,000-fold in elite controllers (EC) compared to typical progressors, but sufficient viral replication persists in EC tissues to allow viral sequence evolution and induce excess immune activation. Here, we show that productive SIV infection...

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Detalles Bibliográficos
Autores principales: Fukazawa, Yoshinori, Lum, Richard, Okoye, Afam A., Park, Haesun, Matsuda, Kenta, Bae, Jin Young, Hagen, Shoko I., Shoemaker, Rebecca, Deleage, Claire, Lucero, Carissa, Morcock, David, Swanson, Tonya, Legasse, Alfred W., Axthelm, Michael K., Hesselgesser, Joseph, Geleziunas, Romas, Hirsch, Vanessa M., Edlefsen, Paul T., Piatak, Michael, Estes, Jacob D., Lifson, Jeffrey D., Picker, Louis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320022/
https://www.ncbi.nlm.nih.gov/pubmed/25599132
http://dx.doi.org/10.1038/nm.3781

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