Restricted isotype, distinct variable gene usage, and high rate of gp120-specificity of HIV-1 Envelope-specific B cells in colostrum compared to those in blood of HIV-1-infected, lactating African women

A successful HIV-1 vaccine must elicit immune responses that impede mucosal virus transmission, though functional roles of protective HIV-1 Envelope (Env)-specific mucosal antibodies remain unclear. Colostrum is a rich source of readily accessible mucosal B cells that may help define the mucosal ant...

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Detalles Bibliográficos
Autores principales: Sacha, C.R., Vandergrift, N., Jeffries, T.L., McGuire, E., Fouda, G.G., Liebl, B., Marshall, D.J., Gurley, T.C., Stiegel, L., Whitesides, J.F., Friedman, J., Badiabo, A., Foulger, A., Yates, N.L., Tomaras, G.D., Kepler, T.B., Liao, H.X., Haynes, B.F., Moody, M.A., Permar, S.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320043/
https://www.ncbi.nlm.nih.gov/pubmed/25100291
http://dx.doi.org/10.1038/mi.2014.69

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