Tungstate-Targeting of BKαβ(1) Channels Tunes ERK Phosphorylation and Cell Proliferation in Human Vascular Smooth Muscle

Despite the substantial knowledge on the antidiabetic, antiobesity and antihypertensive actions of tungstate, information on its primary target/s is scarce. Tungstate activates both the ERK1/2 pathway and the vascular voltage- and Ca(2+)-dependent large-conductance BKαβ(1) potassium channel, which m...

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Detalles Bibliográficos
Autores principales: Fernández-Mariño, Ana Isabel, Cidad, Pilar, Zafra, Delia, Nocito, Laura, Domínguez, Jorge, Oliván-Viguera, Aida, Köhler, Ralf, López-López, José R., Pérez-García, María Teresa, Valverde, Miguel Ángel, Guinovart, Joan J., Fernández-Fernández, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320054/
https://www.ncbi.nlm.nih.gov/pubmed/25659150
http://dx.doi.org/10.1371/journal.pone.0118148

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