Tanshinone IIA Inhibits HIF-1α and VEGF Expression in Breast Cancer Cells via mTOR/p70S6K/RPS6/4E-BP1 Signaling Pathway

Hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) play important roles in angiogenesis and tumor growth. Tanshinone IIA (T2A) is a novel antiangiogenic agent with promising antitumor effects; however, the molecular mechanism underlying the antiangiogenic effects of T...

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Detalles Bibliográficos
Autores principales: Li, Guobing, Shan, Changyu, Liu, Lei, Zhou, Ting, Zhou, Jing, Hu, Xiaoye, Chen, Yibiao, Cui, Hongjuan, Gao, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320086/
https://www.ncbi.nlm.nih.gov/pubmed/25659153
http://dx.doi.org/10.1371/journal.pone.0117440

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