Sub-Cellular Localisation Studies May Spuriously Detect the Yes-Associated Protein, YAP, in Nucleoli Leading to Potentially Invalid Conclusions of Its Function

The Yes-associated protein (YAP) is a potent transcriptional co-activator that functions as a nuclear effector of the Hippo signaling pathway. YAP is oncogenic and its activity is linked to its cellular abundance and nuclear localisation. Activation of the Hippo pathway restricts YAP nuclear entry v...

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Detalles Bibliográficos
Autores principales: Finch, Megan L., Passman, Adam M., Strauss, Robyn P., Yeoh, George C., Callus, Bernard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320119/
https://www.ncbi.nlm.nih.gov/pubmed/25658431
http://dx.doi.org/10.1371/journal.pone.0114813

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