Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis

We report the case of a patient with Rheumatoid Arthritis [RA] presenting with clinical-pathological and radiological features of Pulmonary Lymphomatoid Granulomatosis (PLG). This is a rare lung disorder characterized by multiple nodular lesions with lymphocytic invasion of vascular walls. We presen...

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Detalles Bibliográficos
Autores principales: Barakat, Athar, Grover, Karan, Peshin, Rohit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320142/
https://www.ncbi.nlm.nih.gov/pubmed/25674479
http://dx.doi.org/10.1186/2193-1801-3-751
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author Barakat, Athar
Grover, Karan
Peshin, Rohit
author_facet Barakat, Athar
Grover, Karan
Peshin, Rohit
author_sort Barakat, Athar
collection PubMed
description We report the case of a patient with Rheumatoid Arthritis [RA] presenting with clinical-pathological and radiological features of Pulmonary Lymphomatoid Granulomatosis (PLG). This is a rare lung disorder characterized by multiple nodular lesions with lymphocytic invasion of vascular walls. We present one such case of PLG secondary to Methotrexate and Azathioprine therapy, who was successfully treated with Steroids and Rituximab. We wish to highlight the importance of lung biopsy in the diagnosis and the use of rituximab as a treatment modality for RA as well as PLG. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2193-1801-3-751) contains supplementary material, which is available to authorized users.
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spelling pubmed-43201422015-02-11 Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis Barakat, Athar Grover, Karan Peshin, Rohit Springerplus Case Study We report the case of a patient with Rheumatoid Arthritis [RA] presenting with clinical-pathological and radiological features of Pulmonary Lymphomatoid Granulomatosis (PLG). This is a rare lung disorder characterized by multiple nodular lesions with lymphocytic invasion of vascular walls. We present one such case of PLG secondary to Methotrexate and Azathioprine therapy, who was successfully treated with Steroids and Rituximab. We wish to highlight the importance of lung biopsy in the diagnosis and the use of rituximab as a treatment modality for RA as well as PLG. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2193-1801-3-751) contains supplementary material, which is available to authorized users. Springer International Publishing 2014-12-18 /pmc/articles/PMC4320142/ /pubmed/25674479 http://dx.doi.org/10.1186/2193-1801-3-751 Text en © Barakat et al.; licensee Springer. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Case Study
Barakat, Athar
Grover, Karan
Peshin, Rohit
Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis
title Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis
title_full Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis
title_fullStr Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis
title_full_unstemmed Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis
title_short Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis
title_sort rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320142/
https://www.ncbi.nlm.nih.gov/pubmed/25674479
http://dx.doi.org/10.1186/2193-1801-3-751
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AT peshinrohit rituximabforpulmonarylymphomatoidgranulomatosiswhichdevelopedasacomplicationofmethotrexateandazathioprinetherapyforrheumatoidarthritis

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