Genomic profiling of thousands of candidate polymorphisms predicts risk of relapse in 778 Danish and German childhood acute lymphoblastic leukemia patients

Childhood acute lymphoblastic leukemia survival approaches 90%. New strategies are needed to identify the 10–15% who evade cure. We applied targeted, sequencing-based genotyping of 25 000 to 34 000 preselected potentially clinically relevant single-nucleotide polymorphisms (SNPs) to identify host ge...

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Detalles Bibliográficos
Autores principales: Wesołowska-Andersen, A, Borst, L, Dalgaard, M D, Yadav, R, Rasmussen, K K, Wehner, P S, Rasmussen, M, Ørntoft, T F, Nordentoft, I, Koehler, R, Bartram, C R, Schrappe, M, Sicheritz-Ponten, T, Gautier, L, Marquart, H, Madsen, H O, Brunak, S, Stanulla, M, Gupta, R, Schmiegelow, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320289/
https://www.ncbi.nlm.nih.gov/pubmed/24990611
http://dx.doi.org/10.1038/leu.2014.205

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