GLP-1–oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice

AIMS/HYPOTHESIS: Oestrogens have previously been shown to exert beta cell protective, glucose-lowering effects in mouse models. Therefore, the recent development of a glucagon-like peptide-1 (GLP-1)–oestrogen conjugate, which targets oestrogen into cells expressing GLP-1 receptors, offers an opportu...

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Detalles Bibliográficos
Autores principales: Schwenk, Robert W., Baumeier, Christian, Finan, Brian, Kluth, Oliver, Brauer, Christine, Joost, Hans-Georg, DiMarchi, Richard D., Tschöp, Matthias H., Schürmann, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320309/
https://www.ncbi.nlm.nih.gov/pubmed/25527001
http://dx.doi.org/10.1007/s00125-014-3478-3

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