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Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening

BACKGROUND: MYC family members are among the most frequently deregulated oncogenes in human cancers, yet direct therapeutic targeting of MYC in cancer has been challenging thus far. Synthetic lethality provides an opportunity for therapeutic intervention of MYC-driven cancers. METHODS: A pooled kina...

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Detalles Bibliográficos
Autores principales:	Zhou, Zongxiang, Patel, Manishha, Ng, Nicholas, Hsieh, Mindy H, Orth, Anthony P, Walker, John R, Batalov, Serge, Harris, Jennifer L, Liu, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320452/ https://www.ncbi.nlm.nih.gov/pubmed/25495526 http://dx.doi.org/10.1186/1471-2407-14-944

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